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PHONE HOTLINE: +41 34 448 14 14E-MAIL: info@mcm-medsys.ch
PHONE HOTLINE: +41 34 448 14 14E-MAIL: info@mcm-medsys.ch

NanoKnife

NanoKnife screen
NanoKnife device
NanoKnife probe

Localization therapy reimagined: The NanoKnife system destroys tumors or lesions without harming supporting structures such as blood vessels. It relies on irreversible electroporation (IRE), a mechanism that selectively targets cell membranes to achieve cell death. 

How it works
  1. Electric field application  
    A series of short, high-voltage, low-energy electrical pulses is delivered between electrodes. This generates an electric field surrounding the target tissue.
  2. Membrane permeabilization
    The electric field reorganizes the lipid bilayer and permanently opens the ion channels of the cell membrane. This triggers the formation of nanopores, a process called irreversible electroporation.
  3. Cell death
    Cells that are exposed to sufficient voltage experience unregulated fluid and ionic shifts. This leads to an apoptotic-like cellular death. 
Clinical benefits
  • reliable ablation within the treatment area without skip lesions
  • increased margin expansion (without negative impact on the rates of erectile function and incontinence in male prostate patients)
  • versatile capacities to treat all segments of the prostate
  • easy integration with treatment duration of approximately 1 hour
  • possibility to ablate across urethra, nerves, and urinary sphincters to ensure treatment of lesions near vital structures while preserving the patient’s quality of life
  • procedures can be repeated if needed and do not interfere with other standard treatments (e.g. surgery, radiotherapy)